SILENCING OF PARP2 BLOCKS AUTOPHAGIC DEGRADATION

Silencing of PARP2 Blocks Autophagic Degradation

Poly(ADP-Ribose) polymerases (PARPs) are enzymes Accessories that metabolize NAD+.PARP1 and PARP10 were previously implicated in the regulation of autophagy.Here we showed that cytosolic electron-dense particles appear in the cytoplasm of C2C12 myoblasts in which PARP2 is silenced by shRNA.The cytosolic electron-dense bodies resemble autophagic ves

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Associations between empirically derived dietary patterns and oxidative stress and inflammation in adults with primary hypothyroidism: a case-control study

Abstract Background Primary hypothyroidism is a common endocrine disorder caused by impaired production of thyroid hormones.Recent studies have shown that dietary habits, oxidative stress, and inflammation may play roles in thyroid hypofunction.Thus, the present article aimed to determine the relationship between major dietary patterns and oxidativ

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Power Grab: Why States Cede Sovereignty to International Law

Sovereignty and the rule of law are the cornerstones of modern-day statehood.Yet, in the aftermath of armed conflict since Walkers Accessories the end of the Second World War, various states have set up courts in order to prosecute war crimes, crimes against humanity, genocide, and aggression, prompting these states to surrender sovereignty in thei

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